Pharmacist
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How does Cold-EEZE® reduce the duration of my cold? |
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Read Suzie´s Answer |

Novick SG, Godfrey JC, Godfrey NJ, Wilder HR. How does zinc modify the common cold? Clinical observations and implications regarding mechanisms of action.Medical Hypotheses. 1996;46:295-302.
Clinical Explanation
The zinc gluconate glycine compound in COLD-EEZE® releases 93% of its ionic zinc
(Zn2+) into the mucosal membranes in the mouth. This is substantially more free zinc
than released by zinc complexes with citrate, mannitol/sorbitol, tartrate, acetate or
citric acid.
The zinc ions readily bind to the (cold-causing) human rhinovirus (HRV) which prevents the virus from binding to somatic cells through intercellular adhesion molecules (ICAM), the docking point for HRV on the surface of nasal epithelial cells subsequently reducing HRV duplication and further infection.
*Theory of ICAM-Receptor Mechanism of Action by Novick SG, Godfrey JC, Godfrey NJ, Wilder HR.